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48PB LEINERREFERÊNCIAS(1) Matsuda, N., Koyama, Y.-I., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S. And Takehana, K. (2006). Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. Journal of Nutrition Science and Vitaminology, Vol. 52, 211-215.(2) Shigemura, Y., Iwai, K., Morimatsu, F., Iwamoto, T., Mori, T., Oda, C., Taira, T., Park, E.Y., Nakamura, Y. and Dato, K. (2009). Effect of prolyl-hydroxyproline (Pro-Hyp), a food- -derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J. Agric. Food Chem., Vol. 57, Iss. 2, 444-449. (3) Iwai, K., Hasegawa, T., Taguchi, Y., Mori- matsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y., Nakabo, Y. And Ohtsuki, K. (2005). Identification of food-derived collagen pep- tides in human blood after oral ingestion of gelatin hydrolysates. J. Agric. Food Chem., Vol. 53, Iss. 16, 6531-6536.(4) Ohara, H., Matsumoto, H. Ito, K., Iwai, K. and Sato, K. (2007). Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral inges- tion of gelatin hydrolysates from different sources. J. Agric. Food Chem., Vol 55, Iss. 4, 1532-1535.(5) Ohara, H., Ichikawa, S., Matsumoto, H., Akiyama, M., Fujimoto, N., Kobayashi, T. And Tajima, S. (2010) Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell prolif- eration and hyaluronic acid synthesis in cul- tured human dermal fibroblasts. The Journal of Dermatology, Vol. 37, Iss.4, 330-338.(6) Ohara, H., Ito, K., Iida, H. And Matsumo- to, H. (2009). Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Nip- pon Shokuhin Kagaku Kogaku Kaishi (J. Soc. Food Sci. Technol.) Vol. 56, Iss. 3, 137-145. (7) Liang, J., Pei, X., Zhang, Z., Wang, N., Wang, J. And Li, Y. (2010). The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague- Dawley male rats. J. Food Sci., Vol. 75, Iss. 8, H230-H238.(8) Zague, V., de Freitas, V., da Costa Rosa, M., Álvares de Castro, G., Jaeger, R.G. and Machado-Santelli, G.M. (2011). Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metal- loproteinase 2 Activity. Journal of Medicinal Food. Vol. 14, Iss. 6, 618-624.(9) Tokudome, Y., Nakamura, K., Kage, M., Todo, H., Sugibayashi, K. and Hashimoto, F. (2012). Effects of soybean peptide and collagen peptide on collagen synthesis innormal human dermal fibroblasts. International Journal of Food Sciences and Nutrition, Vol. 63, Iss. 6, 689-695.(10) Okawa, T., Yamaguchi, Y., Takada, S., Sakai, Y., Numata, N., Nakamura, F., Nagashima, Y., Ikezawa, Z. and Aihara, M. (2012). Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model. J. Dermatol. Sci., Vol. 66, Iss. 2, 136-143.(11) Choi, S.Y., Ko, E.J., Lee, Y.H., Kim, B.G., Shin, H.J., Seo, D.B., Lee, S.J., Kim, B.J. and Kim, M.N. (2013). Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study. Journal of Cosmetic and Laser Therapy – online ahead of print.(12) Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V. and Oesser, S. (2014). Oral supplementation of specific collagen pep- tides has beneficial effects on human skin physi- ology: a double-blind, placebo-controlled study. Skin Pharmacol. Physiol., Vol 27, Iss. 1, 47-55.(13) Kantor, I., Donikyan, L.A., Simon, E. And Wollschlaeger, B. (2002). Results of a study evalu- ating the use of a dietary supplement formula in the management of age-related skin changes in women with moderate to severe wrinkling of the periorbital area. 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Cell Tissue Research, Vol. 311, 393-399. (18) Schunck, M., Schulze, C.H. and Oesser, S. (2006). Disparate efficacy of collagen hydrolysate and glucosamine on the extracellular matrix metabolism of articular chondrocytes. Osteoar- thritis and Cartilage, Vol. 14, Suppl. 114, 199. (19) Oesser, S., Raabe, A. and Schunck, M. (2007). Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ ort mice. Osteoarthritis and Cartilage, Vol. 15, Suppl. C., 94-95.(20) Trč, T. and Bohmová, J. (2011). Efficacy andtolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Orthopaedics, Vol. 35, Iss. 3, 341-348.(21) Ohara, H., Iida, H., Ito, K., Takeuchi, Y., and Nomura, Y. (2010). Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. Bioscience, Biotechnology, Biochemistry, Vol. 74., Iss. 10, 2096-2099. (22) Benito-Ruiz, P., Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza- Peralta, M.A., Vallejo-Flores, C.A., Vargas- López, S.V., Villacís-Tamayo, R.A. and Zurita-Gavilanes, L.A. (2009). A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, Vol. 60, Iss. 1, 99-113.(23) Nakatani, S., Mano, H., Sampei, C., Shimizu, J. and Wada M. (2009). Chon- droprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthritis Cartilage, Vol. 17, Iss. 12, 1620-1627.(24) Clark, K.L., Sebastianelli, W., Flechsen- har, K.R., Aukermann, D.F., Meza, F., Millard, R.L., Deitch, J.R., Sherbondy, P.S., and Albert, A. (2008). 24-Week study on the use of col- lagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinions, Vol. 24, Iss. 5, 1485-1496.(25) Veldorst, M.,A.,B., Nieuwenhuizen, A.G., Hochestenbach-Waelen, A., Westerterp, K.R., Engelen, M.P.K.L., Brummer, R-J., M., Deutz, N., E.P., Westerterp-Platenga, M.S. (2009). A breakfast with alpha-lactalbumin, gelatin, or gelatin + RTP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clinical Nutrition, 28, 147-155* Telma Garcia é gerente de Suporte Técnico e Aplicações da PB LeinerPB Leiner BrasilTel.:(65) 2128-2228www.gelatin.comADITIVOS & INGREDIENTES