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RJR Em comparação, todos os produtos com K2VITAL® DELTA atenderam à reivindicação do rótulo. Os re- sultados dos produtos brasileiros foram ainda menos positivos, com 92% dos produtos de K2 desprotegida + K2 MK-7 Misturada com Dicitrato de Trimagnésio Anidro K2VITAL® DELTA K2 Não Encapsulada (MCC) minerais falhando na reivindicação de rótulo. A Kappa Bioscience e sua vitamina K2VITAL® DELTA estão disponíveis para empresas brasileiras através da RJR Nutrientes e Farmoquímicos Ltda. K2 MK-7 Misturada com Óxido de Magnésio K2 Não Encapsulada (MCC) Os desvios significativos da alegação do rótulo nas formulações com magnésio se devem à alta alcalinidade deste mineral. Para ilustrar, a Kappa realizou testes de es- tabilidade prolongada com K2 e magnésio. K2VITAL® DELTA e também uma K2 de alta pureza sem microencapsulamento (99,5% de pureza da MK-7 totalmente trans) foram misturados com óxido de magnésio e dicitrato de trimagnésio anidro. Apenas K2VITAL® DELTA foi estável por 9 meses. A K2 igualmente pura, mas não protegida, se degrada rapidamente com o óxido de magnésio. Com citrato de magnésio a degradação demora mais, mas o teor de K2 ainda cai abaixo da Alegação Efetiva do Rótulo em apenas três meses. K2VITAL® DELTA REFERÊNCIAS 1. Greenland, P., et al., ACCF/AHA 2007 clinical expert con- sensus document on coronary artery calcium scoring by compu- ted tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Com- puted Tomography. J Am Coll Cardiol, 2007. 49(3): p. 378-402. 2. Bild, D.E., et al., Ethnic differences in coronary calcifica- tion: the Multi-Ethnic Study of Atherosclerosis (MESA). Circu- lation, 2005. 111(10): p. 1313-20. 3. Iribarren, C., et al., Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA, 2000. 283(21): p. 2810-5. 4. Dalmeijer, G.W., et al., Matrix Gla protein species and risk of cardiovascular events in type 2 diabetic patients. Diabetes Care, 2013. 36(11): p. 3766-71. 5. Cranenburg, E.C., et al., Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost, 2010. 104(4): p. 811-22. 6. Ueland, T., et al., Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in sympto- matic aortic stenosis. J Intern Med, 2010. 268(5): p. 483-92. 7. Cranenburg, E.C., L.J. Schurgers, and C. Vermeer, Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost, 2007. 98(1): p. 120-5. 8. Schurgers, L.J., et al., Vitamin K-containing dietary sup- plements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 2007. 109(8): p. 3279-83. 9. Theuwissen, E., et al., Low-dose menaquinone-7 supple- mentation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. Br J Nutr, 2012. 108(9): p. 1652-7. 10. Theuwissen, E., et al., Vitamin K status in healthy volun- teers. Food Funct, 2014. 5(2): p. 229-34. 11. Geleijnse, J.M., et al., Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr, 2004. 134(11): p. 3100-5. 12. Gast, G.C., et al., A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis, 2009. 19(7): p. 504-10. 13. Knapen, M.H., et al., Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost, 2015. 113(5): p. 1135-44. 14. Schurgers, L.J. and C. Vermeer, Determination of phyllo- quinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis, 2000. 30(6): p. 298-307. 15. Gijsbers, B.L., K.S. Jie, and C. Vermeer, Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr, 1996. 76(2): p. 223-9. 16. Sato, T., L.J. Schurgers, and K. Uenishi, Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J, 2012. 11: p. 93. 17. Schurgers, L.J. and C. Vermeer, Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta, 2002. 1570(1): p. 27-32. RJR Nutrientes e Farmoquímicos Ltda. Tel.: (11) 3685-0360 rjr.com.br 58 ADITIVOS | INGREDIENTES